prkag2b protein kinase, AMP-activated, gamma 2 non-catalytic subunit b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkag2bprovided by ZNC
Official Full Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-442
See related: Ensembl:ENSDARG00000001933 AllianceGenome:ZFIN:ZDB-GENE-070912-442
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prkag2; si:dkey-217f4.2; si:ch211-230l11.1
Summary: Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to act upstream of or within regulation of protein serine/threonine kinase activity. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (13056714..13149212)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (13373930..13466426)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of catalytic activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

13056714..13149212

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_691638.8 → XP_696730.4 5'-AMP-activated protein kinase subunit gamma-1 isoform X1

UniProtKB/TrEMBL

A0A8N7UW19, F1QRT4

Related

ENSDARP00000122431.3, ENSDART00000142649.4

Conserved Domains (3) summary

COG0517
Location:403 → 520

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:247 → 376

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:403 → 522

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_005163300.4 → XP_005163357.1 5'-AMP-activated protein kinase subunit gamma-1 isoform X2

UniProtKB/TrEMBL

A0A8M2BAB8

Related

ENSDARP00000150928.1, ENSDART00000192832.1

Conserved Domains (3) summary

COG0517
Location:403 → 520

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:247 → 376

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:403 → 522

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...